简介

1.基本信息

姚长洪（YAO Changhong）

副研究员，硕士生导师

制药与生物工程系

四川大学化学工程学院

四川省成都市武侯区一环路南一段24号，610065

Email: yaochanghong@scu.edu.cn

2.教育和工作经历

2004.9-2008.6：四川大学化学工程学院，生物工程，工学学士

2008.9-2014.1：中国科学院大连化学物理研究所，生物化工，工学博士（硕博连读）

2014.2-2016.6：中国科学院大连化学物理研究所，助理研究员

2016.7-2017.2：中国科学院大连化学物理研究所，副研究员

2017.3至今：四川大学化学工程学院，副研究员

3.学术兼职

中国化工学会会员

中国微生物学会终身会员

SCI期刊Frontiers in Marine Science (Marine Biotechnology) (2019 IF=3.086)编委(2019-)

Bioresource Technology, Energy Conversion and Management, Process Biochemistry, PeerJ, Applied Biochemistry and Biotechnology, Bioengineered等国际知名期刊特邀审稿人

科学研究

1.研究方向/兴趣

微藻固碳与储能物质（碳水化合物和油脂）代谢调控与代谢工程

Ø基于光合固碳的微藻生物质和碳水化合物（淀粉和多糖）同步积累调控

Ø微藻淀粉（糖原）积累关键酶研究

Ø基于多组学的微藻碳水化合物和油脂生物合成机制研究

Ø微藻代谢工程研究

基于微藻的废弃物资源化利用

Ø藻渣元素回收和微藻循环培养

Ø利用废水培养微藻生产储能物质

2.科研项目

四川大学引进人才启动基金，蓝藻光合作用固定CO₂生产海藻糖的基础研究，2017/01-2019/12，主持

国家自然科学基金青年项目，41406177，海洋绿藻亚心形四爿藻淀粉磷酸化酶在淀粉合成过程中的作用途径探讨，2015/01-2017/12，主持

科技部863项目，2014AA022004，微藻生物固碳关键技术与产品开发-微藻多糖和活性多肽多联产关键技术与产品开发，2014/01-2016/12，主研

国家自然科学基金面上项目，31470432，莱茵衣藻蛋白全局聚泛素化对缺氮胁迫响应及其对储能物质代谢调控的机理研究，2015/01-2018/12，参与

辽宁省自然科学基金项目，2014020090，氮缺乏调控下微藻氨基酸差异谱数据库构建及关键氨基酸识别，2014/01-2015/12，参与

辽宁省自然科学基金项目，2012010263，海洋微藻油脂积累的转录组及调控机制研究，2013/01-2015/12，参与

主要成果

1.期刊论文

Ran W, Wang H, Liu Y, Qi M, Xiang Q,Yao CH*, Zhang Y, and Lan X. Storage of starch and lipids in microalgae: Biosynthesis and manipulation by nutrients.Bioresource Technology, 2019, 291: 121894 (Invited review, IF=6.669, 1区TOP)

Qi M,Yao CH*, Sun B, Cao X, Fei Q, Liang B, Ran W, Xiang Q, Zhang Y, and Lan X. Application of an in situ CO₂–bicarbonate system under nitrogen depletion to improve photosynthetic biomass and starch production and regulate amylose accumulation in a marine green microalgaTetraselmis subcordiformis.Biotechnology for Biofuels, 2019, 12: 184 (IF=5.452, 1区TOP)

Liu Q^#,Yao CH^#, Sun Y, Chen W, Tan H, Cao X*, Xue S*, and Yin H*. Production and structural characterization of a new type of polysaccharide from nitrogen-limitedArthrospira platensiscultivated in outdoor industrial-scale open raceway ponds.Biotechnology for Biofuels, 2019, 12: 131 (IF=5.452, 1区TOP)

Yao CH*, Jiang JP, Cao XP, Liu YH, Xue S*, and Zhang YK. Phosphorus enhances photosynthetic storage starch production in a green microalga (Chlorophyta)Tetraselmis subcordiformisin nitrogen starvation conditions.Journal of Agricultural and Food Chemistry, 2018, 66: 10777-10787 (IF=3.571, 1区TOP)

lJiang JP,Yao CH*, Cao XP, Liu YH, Xue S*. Characterization of starch phosphorylase from the marine green microalga (Chlorophyta)Tetraselmis subcordiformisreveals its potential role in starch biosynthesis.Journal of Plant Physiology, 2017, 218: 84-93 (IF=2.833, 3区)

Yao CH^#, Pan YF^#, Lu HB, Wu PC, Meng YY, Cao XP, Xue S*. Utilization of recovered nitrogen from hydrothermal carbonization process byArthrospira platensis.Bioresource Technology, 2016, 212: 26-34 (IF=5.651, 1区TOP)

Yao CH, Wu PC, Pan YF, Lu HB, Chi L, Meng YY, Cao XP, Xue S*, Yang XY. Evaluation of the integrated hydrothermal carbonization-algal cultivation process for enhanced nitrogen utilization inArthrospira platensisproduction.Bioresource Technology, 2016, 216: 381-390 (IF=5.651, 1区TOP)

Chi L^#,Yao CH^#, Cao XP, Xue S*. Coordinated regulation of nitrogen supply mode and initial cell density for energy storage compounds production with economized nitrogen utilization in a marine microalgaIsochrysis zhangjiangensis.Bioresource Technology, 2016, 200: 598-605 (IF=5.651, 1区TOP)

Meng YY^#,Yao CH^#, Xue S*, Yang HB. Application of Fourier transform infrared (FT-IR) spectroscopy in determination of microalgal compositions.Bioresource Technology, 2014, 151: 347-354 (IF=4.494, 1区TOP)

Yao CH, Ai JN, Cao XP, Xue S*. Salinity manipulation as an effective method for enhanced starch production in the marine microalgaTetraselmis subcordiformis.Bioresource Technology, 2013, 146: 663-671 (IF=5.039, 1区TOP)

Yao CH, Ai JN, Cao XP, Xue S*. Characterization of cell growth and starch production in the marine green microalgaTetraselmis subcordiformisunder extracellular phosphorus-deprived and sequentially phosphorus-replete conditions.Applied Microbiology and Biotechnology, 2013, 97: 6099-6110 (IF=3.811, 2区TOP)

Yao CH, Ai JN, Cao XP, Xue S*, Zhang W*. Enhancing starch production of a marine green microalgaTetraselmis subcordiformisthrough nutrient limitation.Bioresource Technology, 2012, 118: 438-444 (IF=4.75, 1区TOP)

姚长洪,吴佩春,曹旭鹏,刘娇,姜君鹏,薛松*.两株筛自大规模生产跑道池的节旋藻性能比较研究.中国生物工程杂志, 2017, 37(5), 28-37 (北大核心，CSCD)

2.会议摘要

Yao CH, Xue S, Liu YH, et al. Dissecting a non-conventional starch biosynthetic pathway in microalgae in response to nitrogen starvation. The 10^thAsia-Pacific Conference on Algal Biotechnology. Sep. 27-30, 2019, Nanchang, China(Oral presentation)

Yao CH, Xue S, Wu PC, et al.Integrated hydrothermal carbonization-algal cultivation process for enhanced nitrogen utilization efficiency inArthrospira platensisproduction. The6^thInternational Conference on Algal Biomass, Biofuels and Bioproducts. Jun. 26-29, 2016, San Diego, CA,USA(Oral presentation)

Yao CH, Xue S, Lu HB, et al. Application of hydrothermal carbonization aqueous phase of polysaccharide-extractedArthrospiraresidue forArthrospiracultivation. The 3^rdInternational Conference on Coastal Biotechnology. Aug. 18-21, 2015, Qingdao,China(Oral presentation)

Yao CH, Wang KY, Cao XP, et al. Metabolic responses of a marine microalgaTetraselmis subcordiformisduring nitrogen and sulfur deprivation-induced starch accumulation revealed by differential proteomics. The 7^thAsian Pacific Phycological Forum. Sep. 20-24, 2014, Wuhan, China (Oral presentation)

YaoCH, Wang HT, Cao XP, et al.The stress extent quantification of microalgae by photosynthetic system II quantum yield and accumulation of target compounds in the proper range of stress extent by nutrient addition. 2012 International Symposium on Advanced Biological Engineering. Oct. 25-29, 2012, Guilin,China(Oral presentation)

Yao CH, Ai JN, Cao XP, et al.Enhancing starch production of a marine green microalgaTetraselmis subcordiformisthrough nutrient limitation. 2012 International Symposium on Advanced Biological Engineering.Oct. 25-29, 2012, Guilin,China(Poster and selected oral presentation)

Yao CH, Chen ZA, Zheng Y, et al. Cultivation of a marine green microalga for starch accumulation. The 9^thInternational Marine Biotechnology Conference. Oct. 8-12, 2010, Qingdao, China (Oral presentation)

3.发明专利

薛松,姚长洪,陆洪斌,等.一种同时提高螺旋藻生物质和多糖产率的方法.授权号：CN 201410639520.7

薛松,姚长洪,张卫,等.微藻培养固定微生物发酵尾气CO₂补充发酵原料的方法.授权号：CN 201110164291.4

薛松,姚长洪,陈兆安,等.一种利用二氧化碳培养海洋绿藻积累淀粉的方法.授权号：CN 201010522883.4

薛松,姚长洪,刘瑞国,等.一种富含精氨酸的螺旋藻培养方法: 201611042390.4

薛松,姚长洪,刘瑞国,等.一种回收利用微藻藻渣用于生产富含多糖螺旋藻的方法: 201510795839.3

4.其它成果

辽宁省地方标准DB 21/T/2289.1—2014《海洋微藻成分分析第1部分：中性脂的测定》，第2起草人

辽宁省地方标准DB 21/T/2289.9—2014《海洋微藻成分分析第9部分：灰分的测定》，第3起草人

辽宁省地方标准DB 21/T/2289.3—2016《海洋微藻成分分析第3部分：酸值的测定》，第2起草人

辽宁省地方标准DB 21/T/2289.4—2016《海洋微藻成分分析第4部分：脂肪酸组成成分的测定》，第2起草人

5.奖励荣誉

2016年：大连市科学技术奖，富油能源微藻培育，二等奖

2017年：中国化工学会年会，最佳口头报告奖

2019年：中国化工学会生物化工专业委员会第三届青年学者论坛，最佳口头报告奖