教授
    赵  刚 教授(博导) - 简介

    个人简介:

    赵刚,四川大学化学工程学院制药与生物工程系教授、博士生导师。1980年和1987年曾分别就读于四川大学化学系和兰州大学化学系,1999年在香港中文大学获博士学位。1987年至1996年在四川大学任教。1999年赴法国在法国国家科学研究中心从事博士后研究。2000年任美国俄亥俄州立大学研究员助理。2003年起在世界500强企业之一的日东电工集团生物制药部任技术总监。

    联系方式: gzhao@scu.edu.cn

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赵  刚 教授(博导) -- 授权专利

已授权专利:

1. Zhao, Gang, Kitaura, Chieko, Liu, Jian, Yu, Lei Peptide nucleic acid based guanidinium compounds, US7700565 B2 2010

2. Zhao, Gang, Yu, Lei, Liu, Jian,Kitaura, Chieko, Wang, Xinghe, Castello, Chris Guanidinium delivery carriers, US7687603 B2 2010

3. Zhao, Gang, Fu, Xiaoli, Yu, Lei Biodegradable cationic polymers, US7700542 B2 2010

4. Niitsu, Yoshiro, Yu, Lei, Liu, Jian, Zhao, Gang, Ma, Nianchun, Van, Sang Drug carriers, US8003621 B2 2011

5. Ravikumar, Vasulinga, Kumar, Raju K., Mori, Kenjirou, Konishi, Tatsuya, Matsunawa, Ayako, Matsumura, Takeo, Kitaura, Cheiko, Zhao, Gang Polymeric beads for oligomer synthesis, US7348391 B2 2011

6. Yu, Lei, Zhao, Gang, Van, Sang, Das, Sanjib Kumar, Feng, Zhongling, Fu, Xiaoli, Wang, Xinghe Polyglutamate-amino acid conjugates and methods EP2206736 B1 2012

7. Zhao, Gang, Fu, Xiaoli, Yu, Lei, Biodegradable Cationic Polymers, EP1799748 B1 2012

8. Yu, Lei, Zhao, Gang, Van, Sang, Das, Sanjib Kumar, Feng, Zhongling, Fu, Xiaoli, Wang, Xinghe, Polyglutamate-Amino Acid Conjugates and Methods, EP1969031 B1 2012

赵  刚 教授(博导) -- 研究工作

研究方向及主要成就:

多年来一直致力于有机合成、有机合成方法学、药用高分子材料等领域的研究工作,近年来在不对称有机合成、核糖核酸和脱氧核糖核酸的合成、金属有机化学、配位化学、晶体学、生物学等领域也有重要的研究成果,曾在Nature》、《J. Am. Chem. Soc.》、《Chemistry & Biology》、《Molecular Microbiology》、《Chem. Eur. J.》、《Organic Letters》、《Organometallics等上发表论文近五十篇,引用次数超过800次。并申请美国、欧洲专利六十项。

作为主要参加者在Nature杂志、作为共同第一作者在Chemistry & Biology杂志上发表了关于新型氨基酸吡咯赖氨酸的全合成与生物活性研究的文章,这两篇文章被国际著名杂志和媒体广泛报道。被誉为解决了近半个多世纪以来遗传基因编码中的一个难题并扩展了遗传基因编码的规则。作为项目技术负责人承担了加州大学重大科研项目和抗肿瘤药物重大国际合作项目。2011年作为四川省百人计划入选者和四川省特聘专家到四川大学从事制药工程领域的研究与开发工作。主要从事抗肿瘤药物的设计、合成、不对称催化、手性识别、纳米运载体系和生物活性等领域的研究。

代表性文章:

1. Zhongling Feng, Gang Zhao, Lei Yu, David Gough, Stephen B. Howell, “Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane”, Cancer Chemotherapy and Pharmacology, 2010, 65, 923-930.

2. Xinghe Wang, Gang Zhao, Sang Van, Lei Yu, David Vera, Stephen B. Howell, “Pharmacokinetics and tissue distribution of PGGA-paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts”, Cancer Chemotherapy and Pharmacology, 2010, 65, 515-526.

3. Changxing Liu, Gang Zhao, Jian Liu, Nianchun Ma, Zongyou Chen, David Gough, and Lei Yu, “Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel” J. Controlled Release, 2009, 140(3), 277-283.

4. Wen-Tai Li, Anirban Mahapatra, David G. Longstaff, Jonathan Bechte, Gang Zhao, Patrick T. Kang, Michael K. Chan and Joseph A. Krzycki, “Specificity of Pyrrolysyl-tRNA Synthetase for Pyrrolysine and Pyrrolysine Analogs”, J. Mol. Biol. 2009, 385, 1156–1164.

5. Zhongling Feng, Gang Zhao and Lei Yu, “Neural Stem Cells and Alzheimer's Disease: Challenges and Hope”, Am J Alzheimers Dis Other Demen. 2009; 24; 52. (Invited review)

6. Mahapatra, A, Srinivasan, G, Richter, KB, Meyer, A, Lienard, T, Zhang, JK, Zhao, G, Kang, PT, Chan, M, Gottschalk, G, Metcalf, WW, Krzycki, JA, “Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp.” Molecular Microbiology 2007, 5, 1306-1318.

7. Carine Bughin, Gang Zhao, Hugues Bienaym , Jieping Zhu, “5-Aminooxazole as an Internal Traceless Activator of C-Terminal Carboxylic Acid: Rapid Access to Diversely Functionalized Cyclodepsipeptides”, Chem. Eur. J. 2006, 4, 1174-1184.

8. Sherry K. Blight, Ross C. Larue, Anirban Mahapatra, David G. Longstaff, Edward Chang, Gang Zhao, Patrick T. Kang, Kari B. Green-Church, Michael K. Chan and Joseph A. Krzycki, “Direct charging of tRNACUA with pyrrolysine in vitro and in vivo”, Nature (London, United Kingdom), 2004, 431 (7006), 333-335.

9. Bing Hao, Gang Zhao, Patrick T. Kang, Jitesh A. Soares, Tsuneo K. Ferguson, Judith Gallucci, Joseph A. Krzycki, Michael K. Chan, Reactivity and chemical synthesis of L-pyrrolysine - the 22(nd) genetically encoded amino acid”, Chemistry & Biology 2004,11 (9): 1317-1324.

10. Gang Zhao, Xiaowen Sun, Hugues Bienaymé, and Jieping Zhu, “Activation of a Terminal Carboxylic Acid by an Internal Oxazole: A Novel Synthesis of Macrocyclodepsipeptide”, J. Am. Chem. Soc., 2001, 123, 6700.

11. Xiaowen Sun, Pierre Janvier, Gang Zhao, Hugues Bienaymé, and Jieping Zhu, “A Novel Multicomponent Synthesis of Polysubstituted 5-Aminooxazole and Its New Scaffold-Generating Reaction to Pyrrolo[3,4-b]pyridine”, Organic Letters, 2001, 6, 877.

12. Gang Zhao, Qingchuan Yang, and Thomas C. W. Mak, "Cyclic ether induced asymmetric cyclopalladation: synthesis, structural determination and alkyne insertion reaction of enantiopure planar chiral cyclopalladated derivatives of ferrocenylimines", Organometallics, 1999, 18, 3626.

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