教授-研究员

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杜开峰

发布时间 :2018年07月12日      阅读量:

    教授/博士生导师

一.个人简介

四川大学化工学院教授,博士生导师。四川省海外高层次留学人才,四川大学“化工之星”优秀人才入选者,四川大学优秀青年学者科研基金获得者。2008年获天津大学工学博士学位,同年入职四川大学,曾赴美国加州大学洛杉矶分校和德国克劳斯塔尔工业大学交流访问。主要从事色谱分离及柱技术、生物质资源化及诊断试剂开发等研究,先后主持国家自然科学基金、企业等十多项科研项目,发表高水平SCI学术论文60多篇,发明专利11项,出版专著和教材5部;科技部科技进步奖评委、教育部和国家自然基金委评审专家;《中国科技论文》编辑委员会委员(2019-2021);Biomed Research International(IF2.88)编辑。

实验室地址:四川大学江安校区第一基础实验楼B415和B417室

实验室网址:https://www.x-mol.com/groups/Du_kaifeng

邮箱:kfdu@scu.edu.cn

二. 科研工作

主持科研项目10余项,其中国家自然科学基金3项,四川大学优秀青年学者科研基金1项,国家高技术项目及企业横向项目3项;在Chem. Eng. Sci., Ind. Eng. Chem. Res.,Chem. Eng. J.和J. Chromatogr. A等国际高水平SCI期刊上发表论文50多篇,它引总次数超过400多次,单篇最高它引次数超过90次,申报11项国家发明专利。担任J. Chromatogr.A和 Chem. Eng. J.等多个国际期刊的特约审稿人。

2.1研究方向

1. 高效生物色谱介质的设计合成与柱技术研究

新型生物色谱材料的研制;高通量、高选择性吸附配基的设计合成及分离材料的表面修饰技术;新型色谱介质在生物和医学工程应用中的基本理论和技术研究。

2. 生物质资源高效化研究

以木质纤维素、琼脂糖等天然高分子为研究对象,研究多糖基功能材料开发及其高效化的基础理论与应用技术,重点涉及材料结构调控、表面修饰及其构校关系研究。

3. 其他功能材料的开发研究

生物活性磁性材料的合成及其在细胞筛选、核酸纯化及免疫检测中的应用;核聚变靶丸的结构设计与合成;二次锂电池用高效电极材料的研制。

2.2科研项目(主持)

1.黄黄蜀葵花高效提制技术研究与产业化开发(20H0750),川大-达州专项资金项目,2020-2022;40万;

2.基于磁诱导聚合技术的有序多孔整体柱制备及其分离方法研究,国家自然科学基金(21676170), 2017-2020;

3.纤维素基多孔整体柱色谱介质的合成与生物分离研究,国家自然科学基金项目(21476144),2015-2018;

4.具有阵列多孔结构的整体柱制备及分离方法研究,四川大学优秀青年学者科研基金(2014SCU04A04),2014-2016;

5.有序多孔有机整体柱的制备及其生物色谱研究,国家自然科学基金(21206097),2013-2015;

6.双孔纤维素微球的制备及放大工艺研究,企业委托项目(12H0487),2012-2015;

7.多层球结构设计与制备方法研究,横向项目(HG2011046 ),2012-2014;

2.3近年发表的代表性论文(均为第一或通讯作者)

1. Tian Yao, Yuxin Liao, Shasha Li, Liangzhi Qiao,Kaifeng Du*, Bisphosphonated-immobilized porous cellulose monolith with tentacle grafting by atom transfer radical polymerization for selective adsorption of lysozyme,Journal of Chromatography A,Volume 1651,2021,462337.

2. Tian Yao, Qiang Li, Hongmei Li, Lianxin Peng, Yang Liu,Kaifeng Du*,Extractive resolution of racemic phenylalanine and preparation of optically pure product by chiral magnetic ionic liquid aqueous two-phase system,Separation and Purification Technology,Volume 274, 2021,119024.

3. Qiao, L., Liang, C. &Du, Kaifeng*. Homogeneous and stable carbon nanotube dispersion assisted by cellulose in NaOH/thiourea aqueous solution. Cellulose ,2021,28,5421-5431;.

4. Liangshen Zhao, Shasha Li, Chao Liang, Liangzhi Qiao,Kaifeng Du*, High-strength and low-crystallinity cellulose/agarose composite microspheres: Fabrication, characterization and protein adsorption, Biochemical Engineering Journal, Volume 166, 2021,107826

5. Liangzhi Qiao, Susu Lei,Kaifeng Du*, High-surface-area interconnected macroporous nanofibrous cellulose microspheres: a versatile platform for large capacity and high-throughput protein separation. Cellulose, 2021,28, 1-12.

6. Liangshen Zhao, Shasha Li, Wenhui Wang, Yinghong Wang,Kaifeng Du*, Preparation and characterization of highly porous cellulose-agarose composite chromatographic microspheres for enhanced selective separation of histidine-rich proteins, Journal of Chromatography A, Volume 1637,2021,461831.

7. Yi Liu, Liangzhi Qiao, Anjing Wang, Yaling Li, Liangshen Zhao,Kaifeng Du*,Tentacle-type poly(hydroxamic acid)-modified macroporous cellulose beads: Synthesis, characterization, and application for heavy metal ions adsorption, Journal of Chromatography A,Volume 1645,2021, 462098.

8. Liangshen Zhao, Chao Liang, Shasha Li,Kaifeng Du*, Study of tentacle-like cationic macroporous cellulose spherical adsorbent for heavy metals, Journal of Cleaner Production, Volume 303, 2021,127114.

9.乔亮智,杜开峰.天然多糖微球的制备及功能应用[J/OL].化工进展:1-10[2021-07-03].1000-6613.2020-2012.

10. Tian Yao,Kaifeng Du*, Simultaneous determination of sulfonamides in milk: In-situ magnetic ionic liquid dispersive liquid-liquid microextraction coupled with HPLC, Food Chemistry, Volume 331,2020, 127342

11. Hao Ai, Liangzhi Qiao, Liangshen Zhao, Shasha Li, andKaifeng Du*,Fabrication and Characterization of Anisotropic Porous Poly(styrene@acrylic acid) Monolith for Enhanced Ability of Heavy Metal Adsorption,Ind. Eng. Chem. Res. 2020, 59, 7816−7824;

12. Tian Yao andKaifeng Du*,Measurement and Correlation of Solubility of Benzothiazolium Ionic Liquids in Ethanol + Ethyl Benzoate,J. Chem. Eng. Data 2020, 65, 777−787;

13. Liangzhi Qiao, Liangshen Zhao,Kaifeng Du⁎,Construction of hierarchically porous chitin microspheres via a novel Dual-template strategy for rapid and High-capacity removal of heavy metal ions,Chemical Engineering Journal 393 (2020) 124818;

14. Liangzhi Qiao, Shasha Li, Yaling Li, Yi Liu,Kaifeng Du*,Fabrication of superporous cellulose beads via enhanced inner cross-linked linkages for high efficient adsorption of heavy metal ions,Journal of Cleaner Production 253 (2020) 120017

15.Kaifeng Du, Tian Yao*, The C–H activated controlled mono- and di-olefination of arenes in ionic liquids at room temperature, RSC Advances,2020, 10,3203-3211;

16. Liangzhi Qiao, Shasha Li,Kaifeng Du*Fabrication and characterization of porous cellulose beads with high strength and specific surface area via preliminary chemical cross-linking reaction for protein separation Biochemical Engineering Journal 153 (2020) 107412 IF3.371

17. Tian Yao, Hao Ai, andKaifeng Du*, High tough and highly porous graphene/carbon nanotubes hybrid beads enhanced by carbonized polyacrylonitrile for efficient dyes adsorption, Microporous and Mesoporous Materials 292 (2020) 109716 IF4.182

18. Chao Liang, Liangshen Zhao, Shasha Li, Liangzhi Qiao, Tao Wang,Kaifeng Du*, Direct preparation of porous cellulose microspheres via a self-growth process on bamboo fibers and their functionalization for specific adsorption of histidine-rich proteins, Journal of Chromatography A, Volume 1633, 2020, 461636,ISSN 0021-9673.

19. Liangzhi Qiao, Yaling Li, Yi Liu, Yinghong Wang,Kaifeng Du, High-strength, blood-compatible, and high-capacity bilirubin adsorbent based on cellulose-assisted high-quality dispersion of carbon nanotubes, Journal of Chromatography A, Volume 1634, 2020, 461659,ISSN 0021-9673.

20.艾浩,王文慧,杜开峰.石墨烯/壳聚糖复合微球的制备及其蛋白质吸附评价[J].中国科技论文,2020,15(12):1352-1358+1370.

21.杜开峰*,乔亮智,纤维素基功能材料,工程科学与技术,综述,2019,51(3),9-16.

22. Liangzhi Qiao,Kaifeng Du*, Construction of porous chitosan microspheres with high special surface area by using agarose as pore-form agent and further functionalized application in bioseparation,Journal of Materials Chemistry B, 2019,7,5510-5519

23. Liangzhi Qiao, Liangshen Zhao, Hao Ai, Yaling Li, Yi Liu, andKaifeng Du*,Diethylaminoethyl-Modified Magnetic Starlike Organic Spherical Adsorbent: Fabrication, Characterization, and Potential for Protein Adsorption,Ind. Eng. Chem. Res., 2019, 58 (10), pp 4099–4107

24. Tian Yao, andKaifeng Du*,Temperature-Controlled Mono- and Diolefination of Arene Using Rh(III)/RTIL as an Efficient and Recyclable Catalytic System,ACS Sustainable Chem. Eng.,2019,7(6), pp 6068–6077

25.Kaifeng Du,*Shikai Li, Liangshen Zhao, Liangzhi Qiao, Hao Ai, and Xiaohong Liu, One-Step Growth of Porous Cellulose Beads Directly on Bamboo Fibers via Oxidation-Derived Method in Aqueous Phase and Their Potential for Heavy Metal Ions Adsorption, ACS Sustainable Chem. Eng.,2018,6(12), pp 17068–17075

26.Kaifeng Du,*Xiaohong Liu, Shikai Li, Liangzhi Qiao, and Hao Ai, Synthesis of Cu2+ Chelated Cellulose/Magnetic Hydroxyapatite Particles Hybrid Beads and Their Potential for High Specific Adsorption of Histidine-Rich Proteins, ACS Sustainable Chem. Eng.,2018,2018,6(9), pp 11578–11586

27.Kaifeng Du*, Shunmin Dan, Reversible Concanavalin A (Con A) ligands immobilization on metal chelated macroporous cellulose monolith and its selective adsorption for glycoproteins, Journal of Chromatography A, 2018, 1548, 37–43

28. Qi Zhang, Shunmin Dan, andKaifeng Du*
Fabrication and Characterization of Magnetic Hydroxyapatite Entrapped Agarose Composite Beads with High Adsorption Capacity for Heavy Metal Removal,Industrial & Engineering Chemistry Research,2017, 56, 8705–8712.

29.Kaifeng Du*, Ionic liquid-regenerated macroporous cellulose monolith: Fabrication, characterization and its protein chromatography, Journal of Chromatography A, 2017, 1494, 40–45

30.Kaifeng Du*, Qi Zhang, Facile fabrication of sulfur entrapped carbonized material as a cathode for high-performance lithium batteries, RSC advances, 2016, 6, 87690-87695.

31.Kaifeng Du*, Qi Zhang, Shunmin Dan, Min Yang, Yonkui, Zhang, Fabrication and characterization of aligned macroporous monolith for high-performance protein chromatography,Journal of Chromatography A, 2016, 1443,111-117;

32.Kaifeng Du*, Min Yang, Qi Zhang, Shunmin Dan
, Highly Porous Polymer Monolith Immobilized with Aptamer (RNA) Anchored Grafted Tentacles and Its Potential for the Purification of Lysozyme,Industrial & Engineering Chemistry Research,2016,52, 499-504;

2.4发明专利(均为第一发明人)

[1]杜开峰、但顺民,一种具有可逆修饰的凝聚素基亲和色谱柱的制备方法,专利号CN201710938099.32020年授权)

[2]杜开峰、张琦、杨敏,一种复合磁性羟基磷灰石大球吸附材料的制备方法,专利号CN201710130967.5(2019年授权)

[3]杜开峰、但顺民,一种星形磁响应有机吸附材料及其制备方法,专利号201710300145.7(2019年授权);

[4]杜开峰、崔旭东、李响、张永奎,一种锂二次电池用硫化聚丙烯腈正极材料的制备方法,专利号ZL201410194569.6 (2017年授权)

[5]杜开峰,李响,一种大孔纤维素色谱微球的绿色合成新方法,专利号201510120168.0

[6]杜开峰,杨敏,一种高度多孔的二氧化钛膜光催化剂的制备方法,专利号201610069356.x

[7]杜开峰,张琦,一种有序大孔整体柱色谱材料的制备方法,专利号201510973319.7

[8]杜开峰,杨敏,一种大孔纤维素色谱微球的绿色合成新方法,专利号201510120168.0。

三.教育教学

3.1课程教学

生物基化学品技术;技术经济和项目管理;制药分离工程;生物分离工程,化工技术经济(研究生课程)。

3.2课程和教材建设

负责的《制药分离工程》课程被认定第二批省级线上线下混合式一流课程(2021年);化工技术经济第三版(副主编,国家级规划教材,化学工业出版社,2012);生物信息学导论(主编,水利水电出版社,2015);化工技术经济第四版(副主编,化学工业出版社,2018),制药分离工程(副主编,2019年,科学出版社);医药技术经济(副主编,2019年,科学出版社)。

3.3教改项目(主持)

主持并完成4项省级、校级教学改革项目

1.生物与制药工程专业一体化创新人才培养模式的探索,四川省项目,2011-2014;

2.生物工程类拔尖创新人才综合培养体系的研究与实践(过程装备与控制工程专业综合改革),四川省项目,2011-2013;

3.《生物能源》课程探究式课堂教学方式改革与实践,川大教(2011)97号,2011-2013;

4.四川大学学术学位研究生教材建设项目《工业技术经济和项目管理》研究生教材,项目编号1030704117006,2017-2019。

四、奖励及其他

1. “四川省海外高层次留学人才”荣誉称号,2014

2.“化工之星”优秀人才奖获得2016

3.四川大学优秀青年学者科研基金获得者2014

4.四川大学优秀共产党员,2014

5.四川大学优秀教师,2014

6.四川大学青年骨干教师奖,2014

7.四川大学青年骨干教师奖, 2011

8.四川大学青年骨干教师奖,2010

9.全国制药工程研究壁报大赛(指导教师)三等奖,2011

10.全国制药工程研究论文大赛(本科组)(指导教师)一等奖,2015

11.四川大学本科优秀毕业论文指导教师)二等奖,2016

12.四川大学学术型社团指导教师优秀奖,2016

13. Certificate of Outstanding Contribution in Reviewing by Journal of Chromatography A 2017

五、本科生科研成果

指导的多组本科生获得国家级和省级大学生创新创业项目支持,多名本科生在全国大赛和学术会议上获得奖项。

1.邱浩然,磁响应星形有机吸附剂材料的制备及性能表征,201710611242,国家级项目;

2.唐彬,多层次中空无机微球的结构设计与制备新方法研究,201210610039,国家级项目;

3.牛俊景,新型多孔疏水吸油碳材料的制备及性能表征,201610610650省级项目;

4.柴德治,有序多孔有机整体柱的制备及其生物色谱研究,项目编号201510610523,省级项目,大学生创新创业训练计划;

5.刘倩获得2015年全国学生制药工程研究征文大赛(本科组)一等奖;

6.本科生张琦在2015年的化工年会上获得优秀论文奖。




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