教授-研究员

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赵 刚

发布时间 :2018年07月12日      阅读量:

    教授

    赵 刚 教授(博导)- 简介

    个人简介:

    赵刚,四川大学化学工程学院制药与生物工程系教授、博士生导师。1980年和1987年曾分别就读于四川大学化学系和兰州大学化学系,1999年在香港中文大学获博士学位。1987年至1996年在四川大学任教。1999年赴法国在法国国家科学研究中心从事博士后研究。2000年任美国俄亥俄州立大学研究员助理。2003年起在世界500强企业之一的日东电工集团生物制药部任技术总监。

    联系方式: gzhao@scu.edu.cn

    赵 刚 教授(博导) -- 授权专利

    已授权专利:

    1.Zhao, Gang, Kitaura, Chieko, Liu, Jian, Yu, LeiPeptide nucleic acid based guanidinium compounds, US7700565 B22010

    2.Zhao, Gang, Yu, Lei, Liu, Jian,Kitaura, Chieko, Wang, Xinghe, Castello, ChrisGuanidinium delivery carriers, US7687603 B22010

    3.Zhao, Gang, Fu, Xiaoli, Yu, LeiBiodegradable cationic polymers,US7700542 B22010

    4.Niitsu, Yoshiro, Yu, Lei, Liu, Jian,Zhao, Gang, Ma, Nianchun, Van, SangDrug carriers, US8003621 B22011

    5.Ravikumar, Vasulinga, Kumar, Raju K., Mori, Kenjirou, Konishi, Tatsuya, Matsunawa, Ayako, Matsumura, Takeo, Kitaura, Cheiko,Zhao, GangPolymeric beads for oligomer synthesis, US7348391 B22011

    6.Yu, Lei,Zhao, Gang, Van, Sang, Das, Sanjib Kumar, Feng, Zhongling, Fu, Xiaoli, Wang, Xinghe Polyglutamate-amino acid conjugates and methods EP2206736 B12012

    7.Zhao, Gang, Fu, Xiaoli, Yu, Lei,Biodegradable Cationic Polymers, EP1799748 B12012

    8.Yu, Lei,Zhao, Gang, Van, Sang, Das, Sanjib Kumar, Feng, Zhongling, Fu, Xiaoli, Wang, Xinghe,Polyglutamate-Amino Acid Conjugates and Methods, EP1969031 B12012

    赵 刚 教授(博导) -- 研究工作

    研究方向及主要成就:

    多年来一直致力于有机合成、有机合成方法学、药用高分子材料等领域的研究工作,近年来在不对称有机合成、核糖核酸和脱氧核糖核酸的合成、金属有机化学、配位化学、晶体学、生物学等领域也有重要的研究成果,曾在《Nature》、《J. Am. Chem. Soc.》、《Chemistry & Biology》、《Molecular Microbiology》、《Chem. Eur. J.》、《Organic Letters》、《Organometallics》等上发表论文近百篇,引用次数超过1000次。并申请美国、欧洲专利六十项。

    作为主要参加者在《Nature》杂志、作为共同第一作者在《Chemistry & Biology》杂志上发表了关于新型氨基酸吡咯赖氨酸的全合成与生物活性研究的文章,这两篇文章被国际著名杂志和媒体广泛报道。被誉为解决了近半个多世纪以来遗传基因编码中的一个难题并扩展了遗传基因编码的规则。作为项目技术负责人承担了加州大学重大科研项目和抗肿瘤药物重大国际合作项目。2011年到四川大学从事制药工程领域的研究与开发工作。主要从事抗肿瘤药物的设计、合成、不对称催化、手性识别、纳米运载体系和生物活性等领域的研究。

    代表性文章:

    1. Shiqi Zhang, Guangxun Li, Ling Li, Xiongfei Deng, Gang Zhao,* Xin Cui, and Zhuo Tang*, Alloxan-Catalyzed Biomimetic Oxidations with Hydrogen Peroxide or Molecular Oxygen, ACS Catalysis, 2020, 10, 245−252

    2. Xiongfei Deng, Yingwei Wang, Shiqi Zhang, Ling Li, Guangxun Li,* Gang Zhao* and Zhuo Tang, An organocatalytic asymmetric Friedel–Crafts reaction of 2-substituted indoles with aldehydes: enantioselective synthesis of a-hydroxyl ketones by low loading of chiral phosphoric acid, Chem. Comm., 2020, 56, 2499--2502

    3. Haihang ZhaoYuan Cao Yanjing Zhang Yangyang Zhou Gang Zhao* Lin Pu* Spectroscopic studies of a BINAM-based sensor: Highly selective fluorescent recognition of lysine in water solution through a nucleophilic substitution reaction, Tetrahedron Letters 2019601238-1242

    4. Haihang ZhaoYuan CaoYanjing ZhangYangyang ZhouGang Zhao* Lin Pu* Study of the Zn-II Complexes of 1,1-Binaphthyl-Based Schiff Bases: Fluorescent Detection of Thiocyanate, Eur. J. Inorg. Chem.  2018, 37, 4153-4157

    5. Guidong Gong, Yuan Cao, Hongyun Qian, Yangyang Zhou, Haihang Zhao,  Ling Li, Fei Wang*  and  Gang Zhao*, Assessment of the antitumor activity of a cyclopalladated ferrocene compound assisted by a dual-targeting drug delivery system, Chem. Commun., 2018, 54(60), 8312 -8315

    6. Guidong Gong, Yuan Cao, Fei Wang*, and Gang Zhao* Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells, Organometallics, 2018, 37(7), 1103–1113

    7. Yanjin Zhang, Gang Zhao*, Lin Pu*Diastereoselective [4+1] Cycloaddition of Alkenyl Propargylic Tertiary Acetates with CO Catalyzed by [RhCl(CO)2]2Eur. J. Org. Chem.2017477026-7033

    8. Yingwei Wang, Guangxun Li, Hongxin Liu, Zhuo Tang*, Yuan Cao and Gang Zhao*A tandem annulation with a [1,3]-hydride transfer as the key step leading to isochromansChem. Commun., 2017, 53, 10652—10655

    9. Ting Song, Yuan Cao, Gang Zhao*, and Lin Pu*, Fluorescent Recognition of Zn2+ by Two Diastereomeric Salicylaldimines: Dramatically Different Responses and Spectroscopic InvestigationInorg. Chem.2017, 56, 4395−4399

    10. Shiqi Zhang, Guangxun Li, Hongxin Liu, Yingwei Wang, Yuan Cao, Gang Zhao* and Zhuo Tang*Bio-inspired enantioselective full transamination using readily available cyclodextrinRSC Advances, 2017, 7, 4203–4208





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